If the medicine or treatment cannot be replaced by other equally effective ones that are included in the POS and if not receiving the treatment causes great pain or endangers life, the EPS must provide it. It is important to remember that the doctor who prescribed the medicine or treatment must be a doctor of the health entity with which the person is affiliated (Sentencias SU- 819/99, T-065/04, T-190/04, T-202/04, T-221/04, T-239/04, T-253/04, T-268/04, T-271/04, T-326/04, T-341/04, T-342/04, T-343/04, T367/04, T-372/05, T-434/06, T-1175/08, T-438/09, T-868/12).